068- Dr. Felipe Duarte – Neurobiology related to chronic musculoskeletal conditions and spinal manipulation

Dr. Felipe C. K. Duarte graduated from Feevale University-Brazil in 2008. He has clinical experience as a chiropractor and three other degrees (postgrad dip: Exercise Physiology; MSc: Human Physiology; PhD: Neuroscience). Between 2019 and 2023, he held a research-intensive position at CMCC-Toronto as a postdoctoral fellow and research associate in a rehab research-focused hospital (KITE-Toronto Rehab Institute-UHN, Toronto). Since 2023 Felipe is a senior lecturer at the School of Health, Medical and Applied Sciences, Chiropractic Discipline, Central Queensland University, Australia. He also holds Adjunct professor status at the Canadian Memorial Chiropractic College.

His research interests aim to (1) investigate the neurobiological and neuromechanical mechanisms underlying highly prevalent disabling chronic musculoskeletal conditions, such as chronic spinal pain, neuropathic pain, fibromyalgia, myofascial pain syndrome, and osteoarthritis, which are of great concern to public health systems; (2) Investigate the underlying mechanisms of rehab strategies such as force-based mechanotherapy (e.g., spinal manipulation), focusing on the neurobiological and neuro-immune factors; (3) use these biological determinants to explore their potential for patient stratification in chronic MSK conditions and to spinal manipulation (e.g., responders x non-responders).

Felipe has experience in various methodologies and study designs to address his research interests, which range from molecular biology to neuroimaging and clinical epidemiology. Felipe also possesses direct teaching experience in Biochemistry, Physiology, Neuromusculoskeletal Anatomy, Neuroanatomy, and Clinical Neurological Assessment and Diagnosis at both undergraduate and postgraduate levels.

Visit Dr. Duarte’s research at researchgate.net and view his faculty page.

Here are the articles we discuss during this episode:

1.
Myofascial Pain as an Unseen Comorbidity in Osteoarthritis: A Scoping Review.
Duarte FCK, Chien R, Ghazinour G, Murnaghan K, West DWD, Kumbhare DA.
Clin J Pain. 2023 Apr 1;39(4):188-201. doi: 10.1097/AJP.0000000000001102.
PMID: 36943163 Review.
2.
Effects of Distinct Force Magnitude of Spinal Manipulative Therapy on Blood Biomarkers of Inflammation: A Proof of Principle Study in Healthy Young Adults.
Duarte FCK, Funabashi M, Starmer D, Partata WA, West DWD, Kumbhare DA, Injeyan S.
J Manipulative Physiol Ther. 2022 Jan;45(1):20-32. doi: 10.1016/j.jmpt.2022.03.012. Epub 2022 Jun 25.
PMID: 35760595 Clinical Trial.
3.
Re-Examining Myofascial Pain Syndrome: Toward Biomarker Development and Mechanism-Based Diagnostic Criteria.
Duarte FCK, West DWD, Linde LD, Hassan S, Kumbhare DA.
Curr Rheumatol Rep. 2021 Jul 8;23(8):69. doi: 10.1007/s11926-021-01024-8.
PMID: 34236529 Review.
4.
Spinal Manipulation Therapy Improves Tactile Allodynia and Peripheral Nerve Functionality and Modulates Blood Oxidative Stress Markers in Rats Exposed to Knee-Joint Immobilization.
Duarte FCK, Kolberg C, Riffel APK, Souza JA, Belló-Klein A, Partata WA.
J Manipulative Physiol Ther. 2019 Jul;42(6):385-398. doi: 10.1016/j.jmpt.2018.11.023. Epub 2019 Jul 30.
PMID: 31371096
5.
Spine-Adjusting Instrument (Impulse®) Attenuates Nociception and Modulates Oxidative Stress Markers in the Spinal Cord and Sciatic Nerve of a Rat Model of Neuropathic Pain.
da Silva FBO, Santos MDCQ, da Silva TCB, Facchini D, Kolberg A, Barros RR, Silveira EMS, Kroth A, Duarte FCK, Vassoler JM, Kolberg C, Partata WA.
Pain Med. 2022 Apr 8;23(4):761-773. doi: 10.1093/pm/pnab167.
PMID: 33993301


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