059- Dr. Frank Scali – Upper Cervical Spine and Myodural Bridge

Dr Frank Scali

In this interview, Dr. Scali discusses with me the upper cervical spine and myodural bridge (connective tissue between suboccipital muscles and the cervical spinal dura mater). Dr. Frank Scali grew up in Valley Stream, Long Island, New York, and studied Neuroscience at Stony Brook University. In 2009, he received his Doctorate in Chiropractic at Logan University in Chesterfield, Missouri. During his time in medical school, Dr. Frank Scali professionally prosected cadaveric specimens for Gray’s Anatomy and illustrated for multiple journals and textbooks, including the Oxford Handbook of Bariatric Surgery. While attending medical school, he published multiple non-variant anatomical findings in the medical literature and served as an Ad Hoc Reviewer in Journals such as The Spine Journal, The Anatomical Record, Surgical and Radiological Anatomy, and others. In 2018, he graduated with his MD from AUC School of Medicine with fifty-four publications, including textbook contributions and a patent for a medical device.

Dr. Scali is board certified in Chiropractic and Medicine. His current title is Assistant Professor of Medical Education and Anatomy at the California University of Science and Medicine. At CUSM, Dr. Scali serves as the Director of the ATLAS Lab Center, is the Director of the USMLE Board Preparation, and is the Course Director for MSK/Derm, Surgical Anatomy, and the Step 1/2CK Board Prep course. He was inducted into the Sigma Xi Scientific Research & Honor Society in 2020 and serves on the Editorial Board for the Journal of Medicine since 2019. As Assistant Professor of Medical Education, Dr. Scali has achieved dozens of teaching awards in Medical Foundations, MSK/Derm, Neuroscience, Reproductive Medicine, and Medical Board Preparation courses. Because of his innovative teaching style, in 2021, Dr. Scali became the inaugural recipient of the Robert Suskind & Leslie Lewinter-Suskind Pre-Clinical Faculty of the Year award.

Visit Dr. Scali’s research at researchgate.net and view his faculty page.

Here are the articles we discuss during this episode:

1.Anatomical connection between the rectus capitis posterior major and the dura mater.Scali F, Marsili ES, Pontell ME.Spine (Phila Pa 1976). 2011 Dec 1;36(25):E1612-4. doi: 10.1097/BRS.0b013e31821129df.PMID: 21278628
2.Investigation of meningomyovertebral structures within the upper cervical epidural space: a sheet plastination study with clinical implications.Scali F, Pontell ME, Nash LG, Enix DE.Spine J. 2015 Nov 1;15(11):2417-24. doi: 10.1016/j.spinee.2015.07.438. Epub 2015 Jul 22.PMID: 26210227
3.Histological analysis of the rectus capitis posterior major’s myodural bridge.Scali F, Pontell ME, Enix DE, Marshall E.Spine J. 2013 May;13(5):558-63. doi: 10.1016/j.spinee.2013.01.015. Epub 2013 Feb 11.PMID: 23406969
4.The Posterior Atlantooccipital Membrane: The Anchor for the Myodural Bridge and Meningovertebral Structures.Scali F, Ohno A, Enix D, Hassan S.Cureus. 2022 May 30;14(5):e25484. doi: 10.7759/cureus.25484. eCollection 2022 May.PMID: 35686279 Free PMC article.
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058- Dr. Carlos Gevers – Mechanisms of Spinal Manipulation, Pain, TNF-Alpha

Dr. Carlos Gevers

Dr. Carlos Gevers joins me to discuss mechanisms of spinal manipulation, particularly as they relate to central sensitization and neuroinflammation. He also shares a study on Tumor Necrosis Factor-Alpha in Urine Samples of Patients With Chronic Low Back Pain Undergoing Chiropractic Care.

Carlos Gevers Montoro is a second-generation chiropractor. He graduated from Life Chiropractic College West in 2003 as Valedictorian and the recipient of the Clinical Excellence Citation award. After practicing for a few years in Spain and France, he was instrumental in the opening of the Madrid College of Chiropractic (MCC), where he still lectures. His contributions at the MCC were mostly related to the clinical sciences. In parallel, he served for seven years as the President of the Spanish Chiropractic Association, being involved in chiropractic politics and policy at the national and international level.

In 2018 he decided to switch gears and take a completely new path in the research arena. He started his PhD in Pain Neurosciences at UQTR – University of Montreal joint program under the supervision of Prof. Mathieu Piché. His PhD studies are partially funded, by a prestigious grant from the Government of Quebec. His line of research and his first publications are mostly focused on mechanisms of spinal manipulation, particularly as they relate to central sensitization and neuroinflammation. These two phenomena seem to be strongly implicated in the development of chronic pain syndrome and other conditions.

Check out Dr. Carlos Gevers researchgate profile page.

Here are the articles we discuss in this episode:

1.Presence of Tumor Necrosis Factor-Alpha in Urine Samples of Patients With Chronic Low Back Pain Undergoing Chiropractic Care: Preliminary Findings From a Prospective Cohort Study.Gevers-Montoro C, Romero-Santiago M, Losapio L, Conesa-Buendía FM, Newell D, Álvarez-Galovich L, Piché M, Ortega-De Mues A.Front Integr Neurosci. 2022 Apr 12;16:879083. doi: 10.3389/fnint.2022.879083. eCollection 2022.PMID: 35492573 Free PMC article.
2.Chiropractic Spinal Manipulation Prevents Secondary Hyperalgesia Induced by Topical Capsaicin in Healthy Individuals.Gevers-Montoro C, Provencher B, Northon S, Stedile-Lovatel JP, Ortega de Mues A, Piché M.Front Pain Res (Lausanne). 2021 Jul 20;2:702429. doi: 10.3389/fpain.2021.702429. eCollection 2021.PMID: 35295504 Free PMC article.
3.Neurophysiological mechanisms of chiropractic spinal manipulation for spine pain.Gevers-Montoro C, Provencher B, Descarreaux M, Ortega de Mues A, Piché M.Eur J Pain. 2021 Aug;25(7):1429-1448. doi: 10.1002/ejp.1773. Epub 2021 Apr 15.PMID: 33786932 Review.
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057- Low Back Pain, The Brain and Movement with Dr. Michael Meier

In this episode, Dr. Meier discusses how people move differently in the presence of (or in anticipation of) pain. Changes in motor control may play an important role in musculoskeletal pain. His lab uses a cross-disciplinary approach that combines neuroscience and movement biomechanics to provide new insights into the role of potential interactions between movement behavior, psychological factors and supraspinal mechanisms in the development and maintenance of persistent low back pain. We’ll touch also on fear avoidance and pain related movement avoidance.  Dr. Michael L. Meier is a senior pain researcher and group leader at the Department of Chiropractic Medicine at the University of Zurich. He received his master’s degree in neuropsychology and his doctorate in cognitive neuroscience from the University of Zurich, focusing on the processing of pain and nociception in the brain. In 2019, he received a grant from the Swiss National Science Foundation (SNF) to study the role of movement behavior and cortical processes in the development and persistence of low back pain. A hallmark of his work is linking research from different disciplines such as biomechanics, neuroscience, and psychology, shedding light on novel interacting pathomechanisms underlying persistent low back pain whose pathoanatomical cause is often unclear.

Please see Dr. Michael Meier’s research profile at researchgate.net.  Further information and links to his research can be found at the Balgrist University Hospital website.

Below are the articles Dr. Michael Meier and I discuss in this episode:

1.
Fear-avoidance beliefs are associated with reduced lumbar spine flexion during object lifting in pain-free adults.
Knechtle D, Schmid S, Suter M, Riner F, Moschini G, Senteler M, Schweinhardt P, Meier ML.
Pain. 2021 Jun 1;162(6):1621-1631. doi: 10.1097/j.pain.0000000000002170.
PMID: 33323888 Free PMC article.
2.
Neural responses of posterior to anterior movement on lumbar vertebrae: a functional magnetic resonance imaging study.
Meier ML, Hotz-Boendermaker S, Boendermaker B, Luechinger R, Humphreys BK.
J Manipulative Physiol Ther. 2014 Jan;37(1):32-41. doi: 10.1016/j.jmpt.2013.09.004. Epub 2013 Nov 12.
PMID: 24229849
3. Identifying Motor Control Strategies and Their Role in Low Back Pain: A Cross-Disciplinary Approach Bridging Neurosciences With Movement Biomechanics.
Schmid Stefan, Bangerter Christian, Schweinhardt Petra, Meier Michael L.
Frontiers in Pain Research. 2021 Aug;(2):42. doi: 10.3389/fpain.2021.715219
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056- Issues with Measurement in Science and Clinical Practice – Dr. Samuel Howarth

Dr. Samuel Howarth

Dr. Samuel Howarth is an Associate Professor, Director of Human Performance Research and the McMorland Family Research Chair in Mechanobiology at the Canadian Memorial Chiropractic College. He also holds adjunct positions at Ontario Tech University, University of Toronto, University of Guelph and Memorial University of Newfoundland. Dr. Howarth obtained his PhD in kinesiology from the University of Waterloo in 2011, focusing on biomechanics and more specifically related to the spine. His current research is directed toward biomechanical analysis of human movement focusing on functional tasks used in daily life and clinical practice. A fundamental component of this work, and scientific inquiry in general, is measurement and data handling. Once a topic primarily relevant to researchers, the proliferation of low-cost sensors capable of providing clinicians with a seemingly unimaginable amount data extends the conversation on the acquisition and interpretation of measurements to the clinical environment.

Please see Dr. Samuel Howarth’s research profile at researchgate.net and check out his google scholar page also.  Further information and links to his research can be found at the Canadian Memorial Chiropractic College website.

Below are the articles Dr. Samuel Howarth and I discuss in this episode:

1.
Investigator analytic repeatability of two new intervertebral motion biomarkers for chronic, nonspecific low back pain in a cohort of healthy controls.
To D, Breen A, Breen A, Mior S, Howarth SJ.
Chiropr Man Therap. 2020 Nov 24;28(1):62. doi: 10.1186/s12998-020-00350-5.
PMID: 33228737 Free PMC article.
2.
Does manual therapy affect functional and biomechanical outcomes of a sit-to-stand task in a population with low back pain? A preliminary analysis.
Carpino G, Tran S, Currie S, Enebo B, Davidson BS, Howarth SJ.
Chiropr Man Therap. 2020 Jan 24;28(1):5. doi: 10.1186/s12998-019-0290-7. eCollection 2020.
PMID: 31998472 Free PMC article.
3.
Grant C, Beach TAC, Hogg-Johnson, Chivers M, Howarth SJ. 
Meas Phys Educ Exerc Sci. 2019 Dec 24;24(1):81-92. doi: 10.1080/1091367X.2019.1707680
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055- Dr. Michael Freeman Discusses Whiplash, Motor Vehicle Collisions and Forensic Medicine

Dr. Michael Freeman

In this discussion, Dr. Michael Freeman talks about his research involving motor vehicle collisions, whiplash and forensic applications. Dr. Michael Freeman is a consultant in forensic medicine, and as such is a member of the Faculty of Forensic and Legal Medicine (FFLM) of the Royal College of Physicians in the United Kingdom. He has provided expert testimony more than 1,200 times in a wide variety of civil and criminal cases, including injury and death litigation, automotive and other product liability, toxic tort litigation, life expectancy, and medical negligence cases, as well as in homicide, assault, and other criminal matters.

Dr. Freeman has published around 220 scientific papers, books, and book chapters, primarily focusing on issues relating to forensic applications of epidemiology and general and specific causation. Research and publication topics include traffic crash-related injury and death, injury biomechanics and injury causation, genocide, cancer epidemiology, chronic pain mechanisms, and adult autologous stem cell therapy, among others. Dr. Freeman is the co-editor and co-author of the authoritative text on forensic applications of epidemiology; Forensic Epidemiology: Principles and Practice, published in 2016.

His published 3-step approach has been adopted by U.S. courts as a generally accepted injury causation methodology, as described in the 2016 10th circuit US DCA Etherton decision.

Dr. Freeman is a tenured associate professor of forensic medicine and epidemiology at Maastricht University Medical Center and a joint clinical professor of psychiatry and public health and preventative medicine at Oregon Health & Science University School of Medicine. He is a fellow of the American College of Epidemiology and the American Academy of Forensic Sciences. Dr. Freeman is a past Fulbright Fellow with the U.S. Department of State in the area of forensic medicine, and holds a diploma of legal medicine with the FFLM in the United Kingdom.

Dr. Freeman holds a doctor of medicine degree from Umeå University in Sweden, a Ph.D. and master’s in public health in epidemiology from Oregon State University, a master’s of forensic medical sciences with the Academy for Forensic Medical Sciences in the UK, a doctor of chiropractic from what is now the University of Western States, and a bachelor’s of science from University of Oregon. He has completed a 2-year fellowship in forensic pathology through Umeå University and the Allegheny County Office of the Medical Examiner.

Please see Dr. Michael Freeman’s research profile at researchgate profile.

Below are the articles Dr. Michael Freeman discusses in this episode:

1.Estimating the number of traffic crash-related cervical spine injuries in the United States; An analysis and comparison of national crash and hospital data.Freeman MD, Leith WM.Accid Anal Prev. 2020 Jul;142:105571. doi: 10.1016/j.aap.2020.105571. Epub 2020 May 12.PMID: 32413544
2.Diagnostic Accuracy of Videofluoroscopy for Symptomatic Cervical Spine Injury Following Whiplash Trauma.Freeman MD, Katz EA, Rosa SL, Gatterman BG, Strömmer EMF, Leith WM.Int J Environ Res Public Health. 2020 Mar 5;17(5):1693. doi: 10.3390/ijerph17051693.PMID: 32150926 Free PMC article.
3.Is Acceleration a Valid Proxy for Injury Risk in Minimal Damage Traffic Crashes? A Comparative Review of Volunteer, ADL and Real-World Studies. Nolet PS, Nordhoff L, Kristman VL, Croft AC, Zeegers MP, Freeman MD.Int J Environ Res Public Health. 2021 Mar 12;18(6):2901. doi: 10.3390/ijerph18062901. PMCID: PMC8001694.
4.A systematic approach to clinical determinations of causation in symptomatic spinal disk injury following motor vehicle crash trauma. Freeman MD, Centeno CJ, Kohles SS. PM R. 2009 Oct;1(10):951-6. doi: 10.1016/j.pmrj.2009.07.009. PMID: 19854423.
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054- Drs. Chris Malaya and Josh Haworth Discuss Motor Control, Posture and Chiropractic

Drs. Christopher Malaya and Joshua Haworth

Drs. Chris Malaya and Josh Haworth discuss motor control, posture and chiropractic research in this episode. Dr. Chris Malaya is a research associate at Parker University in Dallas, Texas. He graduated from Parker in 2018 with a Doctorate in Chiropractic and is currently pursuing a PhD in Motor Control from the University of Houston. His current research interests are in sensorimotor integration, postural control and adaptation, as well as the neural mechanisms of manual manipulation. His overall goal is to help expand the foundational mechanisms and practical applications of manual joint manipulation as it relates to movement and neural rehabilitation.

Dr. Josh Haworth’s research focuses on the mechanisms responsible for the integration of sensorimotor information in the production of human behavior. He uses eye-tracking combined with motion capture and posturographic measures to identify motor strategies used during daily tasks like upright standing, walking, and interpersonal communication. Extensions of this work include the identification of early indicators of clinical disorders and the production of novel therapeutic modalities. He has many active collaborations with colleagues in fields including chiropractic science and pediatric rehabilitation technology. He is focused to better understand the development of motor and social-cognitive skills in children with, and without, autism. 

View Dr. Christopher Malaya’s research at Parker University and researchgate.net and Dr. Josh Haworth’s research at Oakland University and researchgate.net.

Below are the studies that Drs. Chris Malaya and Josh Haworth discuss in this interview.

1.Immediate impact of extremity manipulation on dual task performance: a randomized, crossover clinical trial.Malaya CA, Haworth J, Pohlman KA, Smith DL.Chiropr Man Therap. 2021 Feb 5;29(1):6. doi: 10.1186/s12998-021-00366-5.PMID: 33541378 Free PMC article.
2.Impact of Extremity Manipulation on Postural Sway Characteristics: A Preliminary, Randomized Crossover Study.Malaya CA, Haworth J, Pohlman KA, Powell C, Smith DL.J Manipulative Physiol Ther. 2020 Jun;43(5):457-468. doi: 10.1016/j.jmpt.2019.02.014. Epub 2020 Aug 14.PMID: 32800642
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053- Dr. Joyce Miller and Evidence Based Chiropractic Care for Infants

Dr. Joyce Miller

Dr. Joyce Miller, semi-retired, is a guest paediatrics researcher at AECC University College, Bournemouth, England. She previously worked full-time as Lead Tutor for MSc Musculoskeletal Health of Paediatrics, undergrad paediatrics and evidence based clinical practice at AECC University College. An Associate Professor, she pioneered the busy infant and child practice in the teaching clinic approximately 25 years ago at AECC.  She is a busy researcher and has authored more than 80 articles published in peer reviewed journals and conducted over 180 seminars world-wide.  She was a certified Brazelton neonate examiner, awarded from Cambridge University and a diplomat of the Royal College Paediatrics and Child Health Nutrition Programme and a fellow of the Royal College of Chiropractors and British Chiropractic Association.  Along with Bournemouth University’s midwifery team from the School of Health and Social Care, in 2013 has developed an AECC-BU breastfeeding clinic located on the University Campus. This is an inter-disciplinary clinic where midwives and chiropractors (and students) manage difficult feeding cases together and learn together. She focuses on the care of the neonate and infants, obtaining her PhD in musculoskeletal health of the infant in 2013. She has undergraduate degrees in education and psychology and a post-graduate diplomate in chiropractic orthopaedics. She authored the book, Evidence Based Chiropractic Care for Infants in 2019, co-edits Journal Clinical Chiropractic Pediatrics and continues to mentor graduate students.

View Dr. Miller’s research on researchgate.com.

Here is a link to purchase Dr. Miller’s book, from the publisher and from Amazon.

Evidence Based Chiropractic Care for Infants

Here are the articles we discuss in this episode:

1.
Maternal Report of Outcomes of Chiropractic Care for Infants.
Miller JE, Hanson HA, Hiew M, Lo Tiap Kwong DS, Mok Z, Tee YH.
J Manipulative Physiol Ther. 2019 Mar-Apr;42(3):167-176. doi: 10.1016/j.jmpt.2018.10.005. Epub 2019 Apr 25.
PMID: 31029467
2.
Long-term effects of infant colic: a survey comparison of chiropractic treatment and nontreatment groups.
Miller JE, Phillips HL.
J Manipulative Physiol Ther. 2009 Oct;32(8):635-8. doi: 10.1016/j.jmpt.2009.08.017.
PMID: 19836599
3.
Efficacy of chiropractic manual therapy on infant colic: a pragmatic single-blind, randomized controlled trial.
Miller JE, Newell D, Bolton JE.
J Manipulative Physiol Ther. 2012 Oct;35(8):600-7. doi: 10.1016/j.jmpt.2012.09.010.
PMID: 23158465 Clinical Trial.
4.
 Risks and rewards of early musculoskeletal assessment: An evidence-based case report
Joyce Miller, Marcella Fontana, Karin Jernlås, Henny Olofsson, Ida Verwijst.
British Journal of Midwifery VOL. 21, NO. 10. https://doi.org/10.12968/bjom.2013.21.10.736

View another chiropractic pediatric podcast episode.

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052- Dr. Ken Weber Discusses Advanced MRI Techniques, Pain & Manual Therapy

Dr. Ken Weber

Dr. Ken Weber and I discuss his research pursuits which involve: 1) developing imaging modalities that are more sensitive and specific to the pathology, providing more diagnostic, prognostic, and predictive information; 2) providing more quantitative information to the clinician; and 3) using these measures to better understand the nervous system and how it functions, the neurophysiology of pain, how treatments work, and why certain treatments work for some patients but not for others. Dr. Ken Weber is an Instructor in the Department of Anesthesia, Perioperative and Pain Medicine at Stanford University. He obtained his Doctor of Chiropractic from Palmer College of Chiropractic Florida in 2009 and then completed a PhD in neuroscience at Northwestern University in 2016, specializing in movement and rehabilitation science. Ken’s research intersects clinical pain research and advanced MRI techniques with an emphasis on brain, spinal cord, and musculoskeletal imaging. His research aims to better understand the neural and musculoskeletal changes underlying clinical pain conditions, the mechanisms of treatments, and predictors for recovery. Ken is currently supported by a K23 Mentored Patient-Oriented Research Career Development Award from the National Institute of Neurological Disorders and Stroke of the National Institutes of Health. His previous funding has included the National Center for Complementary and Integrative Health, the National Institute on Drug Abuse, and the NCMIC Foundation, Inc.

I’d also like to point out that Ken was recently selected to be part of the CARL (Chiropractic Academy for Research Leadership) program. 

View Dr. Weber‘s research at researchgate.net.

Here are some of the papers we discuss in this episode.

1. Machine Learning for the Prediction of Cervical Spondylotic Myelopathy: A Post Hoc Pilot Study of 28 Participants.
  Hopkins BS, Weber KA 2nd, Kesavabhotla K, Paliwal M, Cantrell DR, Smith ZA.
  World Neurosurg. 2019 Jul;127:e436-e442. doi: 10.1016/j.wneu.2019.03.165. Epub 2019 Mar 25.
  PMID: 30922901 [PubMed – indexed for MEDLINE]
  Similar articles
2. Are Magnetic Resonance Imaging Technologies Crucial to Our Understanding of Spinal Conditions?
  Crawford RJ, Fortin M, Weber KA 2nd, Smith A, Elliott JM.
  J Orthop Sports Phys Ther. 2019 May;49(5):320-329. doi: 10.2519/jospt.2019.8793. Epub 2019 Mar 26.
  PMID: 30913967 [PubMed – in process]
  Similar articles
3. Lateral Corticospinal Tract Damage Correlates With Motor Output in Incomplete Spinal Cord Injury.
  Smith AC, Weber KA 2nd, O’Dell DR, Parrish TB, Wasielewski M, Elliott JM.
  Arch Phys Med Rehabil. 2018 Apr;99(4):660-666. doi: 10.1016/j.apmr.2017.10.002. Epub 2017 Oct 26.
  PMID: 29107041 [PubMed – indexed for MEDLINE] Free PMC Article
  Similar articles
4. Evidence for decreased Neurologic Pain Signature activation following thoracic spinal manipulation in healthy volunteers and participants with neck pain.
  Weber Ii KA, Wager TD, Mackey S, Elliott JM, Liu WC, Sparks CL.
  Neuroimage Clin. 2019;24:102042. doi: 10.1016/j.nicl.2019.102042. Epub 2019 Oct 18.
  PMID: 31670070 [PubMed – in process] Free PMC Article
  Similar articles
5. Deep Learning Convolutional Neural Networks for the Automatic Quantification of Muscle Fat Infiltration Following Whiplash Injury.
  Weber KA, Smith AC, Wasielewski M, Eghtesad K, Upadhyayula PA, Wintermark M, Hastie TJ, Parrish TB, Mackey S, Elliott JM.
  Sci Rep. 2019 May 28;9(1):7973. doi: 10.1038/s41598-019-44416-8.
  PMID: 31138878 [PubMed – in process] Free PMC Article
  Similar articles
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051- Dr. William Reed Discusses Mechanisms of Spinal Manual Therapy

Dr. William Reed is an Associate Professor in the School of Health Professions, Department of Physical Therapy at University of Alabama at Birmingham. He is the director of the Mechanisms of Spinal Manual Therapy Laboratory. His research is directed towards determining the peripheral and central mechanisms of spinal manipulation (manual therapy) for the treatment of musculoskeletal pain.  He is also the Interim Co-Director of the PhD program in Rehabilitation Science at the University of Alabama at Birmingham. Here we discuss some of Dr. William Reed’s research starting with his introduction to research as a chiropractic student in 1994 then we’ll discuss his work with Dr. Joel Pickar, his K01 award topic, and progressing to his latest line of research on characterization of a rat LBP model and spinal mobilization mechanisms. 

See more of Dr. Reed’s research at researchgate.net.

The articles we discuss in this episode include:

1.
Chiropractic management of primary nocturnal enuresis.
Reed WR, Beavers S, Reddy SK, Kern G.
J Manipulative Physiol Ther. 1994 Nov-Dec;17(9):596-600.
PMID: 7884329 Clinical Trial.
2.
Relationship between Biomechanical Characteristics of Spinal Manipulation and Neural Responses in an Animal Model: Effect of Linear Control of Thrust Displacement versus Force, Thrust Amplitude, Thrust Duration, and Thrust Rate.
Reed WR, Cao DY, Long CR, Kawchuk GN, Pickar JG.
Evid Based Complement Alternat Med. 2013;2013:492039. doi: 10.1155/2013/492039. Epub 2013 Jan 20.
PMID: 23401713 Free PMC article.
3.
Paraspinal Muscle Spindle Response to Intervertebral Fixation and Segmental Thrust Level During Spinal Manipulation in an Animal Model.
Reed WR, Pickar JG.
Spine (Phila Pa 1976). 2015 Jul 1;40(13):E752-9. doi: 10.1097/BRS.0000000000000915.
PMID: 25856263 Free PMC article.
4.
Neural responses to the mechanical characteristics of high velocity, low amplitude spinal manipulation: Effect of specific contact site.
Reed WR, Long CR, Kawchuk GN, Pickar JG.
Man Ther. 2015 Dec;20(6):797-804. doi: 10.1016/j.math.2015.03.008. Epub 2015 Mar 27.
PMID: 25841562 Free PMC article.
5.
Spinal Mobilization Prevents NGF-Induced Trunk Mechanical Hyperalgesia and Attenuates Expression of CGRP.
Reed WR, Little JW, Lima CR, Sorge RE, Yarar-Fisher C, Eraslan M, Hurt CP, Ness TJ, Gu JG, Martins DF, Li P.
Front Neurosci. 2020 Apr 30;14:385. doi: 10.3389/fnins.2020.00385. eCollection 2020.
PMID: 32425750 Free PMC article.

 

Check out related chiropractic science podcasts on neurophysiology and the brain.

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050- MRI, Back Pain, Disc Herniations and Modic Changes with Dr. Tue Secher Jensen

Tue Secher Jensen

Tue Secher Jensen graduated from the University of Southern Denmark in 2002 and has been working as a researcher since his student years. After graduation, he worked as a chiropractic intern and as a chiropractor for a couple of years alongside his work as a research assistant. In 2009, he defended his PhD thesis on the prevalence, development and clinical value of Modic changes in the general population. From 2013 to 2016, he was employed as a senior researcher and clinical associate professor at the Spine Centre of Southern Denmark and since 2013 he has also been employed as a senior researcher at the Nordic Institute of Chiropractic and Clinical Biomechanics (NIKKB). Since 2017, Tue Secher Jensen has been employed at the Diagnostic Centre – Imaging Sector at the Regional Hospital in Silkeborg, Denmark, as a chiropractor doing research and reading spinal MRI. From 2018 to 2019 he was an associate professor at the Department of Clinical Medicine at Aarhus University. Tue Secher Jensen was recently (January 1st 2020) appointed, along with Lise Hestbaek (who has previously been on the podcast), as professors at the Department of Sports Science and Clinical Biomechanics at SDU.

Tue’s research has primarily focused on the clinical value of MRI findings in people with back pain. In recent years his research focus has shifted more towards clinical guidelines, knowledge translation and implementation.

See more of Tue’s research at researchgate.net.

The articles we discuss in this episode include:

1. Systematic literature review of imaging features of spinal degeneration in asymptomatic populations.
  Brinjikji W, Luetmer PH, Comstock B, Bresnahan BW, Chen LE, Deyo RA, Halabi S, Turner JA, Avins AL, James K, Wald JT, Kallmes DF, Jarvik JG.
  AJNR Am J Neuroradiol. 2015 Apr;36(4):811-6. doi: 10.3174/ajnr.A4173. Epub 2014 Nov 27. Review.
  PMID: 25430861 [PubMed – indexed for MEDLINE] Free PMC Article
  Similar articles
2. MRI Findings of Disc Degeneration are More Prevalent in Adults with Low Back Pain than in Asymptomatic Controls: A Systematic Review and Meta-Analysis.
  Brinjikji W, Diehn FE, Jarvik JG, Carr CM, Kallmes DF, Murad MH, Luetmer PH.
  AJNR Am J Neuroradiol. 2015 Dec;36(12):2394-9. doi: 10.3174/ajnr.A4498. Epub 2015 Sep 10. Review.
  PMID: 26359154 [PubMed – indexed for MEDLINE] Free Article
  Similar articles
3. Magnetic resonance imaging findings as predictors of clinical outcome in patients with sciatica receiving active conservative treatment.
  Jensen TS, Albert HB, Sorensen JS, Manniche C, Leboeuf-Yde C.
  J Manipulative Physiol Ther. 2007 Feb;30(2):98-108.
  PMID: 17320730 [PubMed – indexed for MEDLINE]
  Similar articles
4. Natural course of disc morphology in patients with sciatica: an MRI study using a standardized qualitative classification system.
  Jensen TS, Albert HB, Soerensen JS, Manniche C, Leboeuf-Yde C.
  Spine (Phila Pa 1976). 2006 Jun 15;31(14):1605-12; discussion 1613.
  PMID: 16778696 [PubMed – indexed for MEDLINE]
  Similar articles
5. Modic changes, possible causes and relation to low back pain.
  Albert HB, Kjaer P, Jensen TS, Sorensen JS, Bendix T, Manniche C.
  Med Hypotheses. 2008;70(2):361-8. Epub 2007 Jul 10.
  PMID: 17624684 [PubMed – indexed for MEDLINE]
  Similar articles
6. Vertebral endplate signal changes (Modic change): a systematic literature review of prevalence and association with non-specific low back pain.
  Jensen TS, Karppinen J, Sorensen JS, Niinimäki J, Leboeuf-Yde C.
  Eur Spine J. 2008 Nov;17(11):1407-22. doi: 10.1007/s00586-008-0770-2. Epub 2008 Sep 12. Review.
  PMID: 18787845 [PubMed – indexed for MEDLINE] Free PMC Article
  Similar articles
7. Modic changes-Their associations with low back pain and activity limitation: A systematic literature review and meta-analysis.
  Herlin C, Kjaer P, Espeland A, Skouen JS, Leboeuf-Yde C, Karppinen J, Niinimäki J, Sørensen JS, Storheim K, Jensen TS.
  PLoS One. 2018 Aug 1;13(8):e0200677. doi: 10.1371/journal.pone.0200677. eCollection 2018.
  PMID: 30067777 [PubMed – indexed for MEDLINE] Free PMC Article
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8. Antibiotic treatment in patients with chronic low back pain and vertebral bone edema (Modic type 1 changes): a double-blind randomized clinical controlled trial of efficacy.
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